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What is Opill (Norgestrel Tablet)?

October 4, 2024

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A woman is holding a blister pack of pills and a glass of water.

What is Opill? Put simply, it's a birth control pill approved by the FDA in 1973 but only recently approved for over-the-counter purchase. It's the only birth control pill that women are able to buy without a prescription.

How Does Opill Work?

Each Opill tablet contains 0.075 mg of Norgestrel. This is a synthetic form of progesterone, a hormone that can prevent pregnancy in two ways. First, it makes it difficult for an egg to meet sperm. Second, it prevents a fertilized egg from implanting in the womb. However, it is only effective in preventing fertilization about 50% of the time but prevents pregnancy about 98% of the time when used properly. Opill is actually an abortifacient. Research clearly shows that life begins at fertilization, which is the moment when a sperm meets a fertilized egg, which means that Opill is not only preventing the formation of life but, in many instances, ending a life that's already begun.

Opill Considerations

Over-the-counter medications aren't a substitute for regular medical care. An annual check-up that includes a pap smear and STI testing will enable you to catch potentially serious health problems while they're still small. It's also a good idea to talk to your doctor about using Opill, as he or she will be able to offer personalized medical advice that could affect your decisions. At the same time, don't rely only on your doctor to tell you how to care for your body. All medications, including over-the-counter medications, can have negative side effects, and Opill is no exception. Ryalynn Morgan Carter, MD, an obstetrician-gynecologist and assistant professor of OB/GYN at Columbia University Vagelos College of Physicians and Surgeons, recently explained this in an article written for Columbia University Irving Medical Center. She notes, "Common side effects [of Opill] are headaches, dizziness, nausea, increased appetite, abdominal pain, cramps, bloating and abnormal breakthrough bleeding."


There is also a long list of uncommon side effects, some of which could put your health in serious jeopardy. Norgestrel, the main ingredient in Opill, can affect your mental health by causing or exacerbating depression. Norgestrel can also cause unwanted facial and/or body hair growth, swelling in the ankles, pelvic pain, lumps in one or both breasts, dark urine, yellowing skin and/or eyes, fatigue, rashes, itching and/or swelling, severe dizziness, trouble breathing and blood clots. What's more, medical professionals warn that these aren't the only potential side effects. If you take a Norgestrel tablet and feel something isn't right, call your doctor or seek immediate medical help.


It should also be noted that Opill isn't as effective in preventing pregnancy as other birth control pills. Because it lacks estrogen, it is not as effective in preventing sperm from meeting a fertilized egg as birth control tablets that use estrogen. Birth Control Pills that include estrogen have other serious side effects like high blood pressure, and clotting that can lead to a stroke. You should seek care from your ObGyn before taking a new birth control pill. Norgestrel must be taken at the same time each day because taking a tablet even three hours late can increase your odds of an unplanned pregnancy if you're sexually active.

How Does It Differ from Other Birth Control?

There are many similarities between Opill and other birth control tablets. Norgestrel, the active ingredient in Opill, is also used by other brands of birth control pills as some women can't take birth control pills containing estrogen. Like other birth control pills, Opill must be taken once a day. It can’t be emphasized enough, Opill must be taken at the same time each day to be fully effective, which isn't the case with other birth control tablets.


Effectiveness ratings of Opill are assuming the user will follow the directions perfectly.

Naturally, hormone-based birth control pills aren't the only birth control option to consider. Barrier birth control such as using a condom or diaphragm isn't as effective in preventing pregnancy as hormonal birth control. However, they are affordable and won't adversely affect your mental and physical health. 


Abstinence is the safest, most effective way to prevent an unplanned pregnancy if you aren't in a committed relationship. Those who are married and do not wish to become pregnant may want to consider barrier birth control combined with the natural family planning method. This method, also known as NFP, involves tracking your hormonal cycle to determine when you're most likely to ovulate, so you can avoid sexual activity during this time period. NFP when tracked carefully can be very effective. The Billings Method of NFP touts 100% success at preventing pregnancy when the method is carefully followed. Schedule a time to meet with our nurse to learn about NFP today!


Are you wondering which form of birth control would work best for you? Do you suspect you may be pregnant, or are experiencing symptoms of pregnancy but tested negative when using an at-home pregnancy test? Pregnancy Care Clinic offers professional medical care and services to help you safely and effectively manage your reproductive health. Our services are free and include pregnancy testing, an ultrasound, STI testing, medical referrals, and more information about birth control.


PCC does not prescribe or refer for birth control.


But we are pleased to provide all the information you will need to make an informed choice. If you or someone you know would benefit from our services, get in touch with us at your convenience to find out more, or pay a visit to one of our clinics to get the help you need and deserve.

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